5 Best Formulas for Colic and Spit-Up: Calming & Soothing Relief

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5 Best Formulas for Colic and Spit-Up: Calming & Soothing Relief

Soothe your baby's tummy troubles with the best formulas for colic and spit-up

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By Staci Gulbin
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Edited by Caitlin Snethlage

Published November 28, 2024.

A baby sleeping next to a bottle of baby formula

Do your baby's cries feel like a constant, piercing alarm with no off switch? Welcome to the rollercoaster of parenting a colicky infant. The endless nights of trying to soothe a distressed baby can leave even the most patient parents feeling overwhelmed—especially when every feeding seems to end in an eruption of spit-up.

But here's the good news: the right formula can be your secret weapon in turning those endless, tear-filled nights into peaceful, manageable moments.

» Don't let colic and spit-up disrupt your baby's (and your) sleep. Find the perfect formula now

Our Pick: Best Formulas for Colic and Spit-Up

  1. Best overall formula for colic and spit up: Else Nutrition Plant-Based Complete Nutrition Formula
  2. Best quick-relief formula for colic and spit-up: Gerber Good Start SoothePro
  3. Best formula for colic and spit-up for sensitive tummies: Similac 360 Total Care Sensitive Infant Formula
  4. Best formula for colic and spit-up settling for reducing gas: Mama Bear Gentle Premium Baby Formula Powder
  5. Best soothing formula for colic and spit-up for fussy babies: Enfamil Nutramigen
Best overall formula for colic and spit-up
1
Superior
10

Else Nutrition Plant-Based Complete Nutrition Formula

Nourishing little ones naturally

Best quick-relief formula for colic and spit-up
2
Outstanding
9.8

Gerber Good Start SoothePro

Feeding little tummies

Best formula for colic and spit-up for sensitive tummies
3
Excellent
9.6

Similac® 360 Total Care® Sensitive* Infant Formula

A trusted choice for parents

Show more



What Are Colic and Spit-Up?

Colic and excessive spit-up are common infant issues that often go hand in hand. Colic, characterized by prolonged, intense crying spells, can be distressing for both baby and parent. Excessive spit-up, or reflux, occurs when stomach contents flow back into the esophagus.

Why Do These Issues Happen?

The root cause of both colic and spit-up lies in the immaturity of an infant's digestive system. A baby's digestive tract is still developing, and it can take time to coordinate complex functions like muscle contractions, enzyme production, and nutrient absorption. This developmental process can lead to:

  • Immature Muscle Function: Weak or uncoordinated muscle contractions in the esophagus and stomach can allow stomach contents to reflux.

  • Sensitive Digestive System: An infant's digestive system is susceptible to changes in diet, feeding techniques, and environmental factors.

  • Gas and Bloating: Gas buildup in the intestines can cause discomfort and increase crying and fussiness, often associated with colic.

Understanding these underlying factors can help parents manage these common infant challenges and provide comfort to their little ones.

» Discover the signs that formula isn't right for your baby

How Can Formula Help?

Specialized formulas for colic and spit-up often rely on minimally processed ingredients to deliver targeted relief. Here's how:

  1. Lactose-Free Formulas: These formulas offer an alternative protein source, such as soy or a plant-based blend, making them easier to digest for babies with potential lactose sensitivities.
  2. Hydrolyzed Protein Formulas: By breaking down proteins into smaller peptides, these formulas reduce the risk of allergic reactions and digestive discomfort, often alleviating reflux symptoms.
  3. Probiotic Formulas: Probiotics help balance the gut microbiota, promoting healthy digestion and potentially reducing colic symptoms. Recent studies suggest a significant positive impact on infant digestive comfort.
  4. Plant-Based Formulas: These formulas offer a plant-based alternative to cow's milk protein for babies with allergies or intolerances. They are often hypoallergenic and more accessible to digest.
  5. Allergy-Free Formulas: These formulas are specifically designed for babies with multiple food allergies. They use highly hydrolyzed protein and other hypoallergenic ingredients.
  6. Organic Ingredients: USDA-certified formulas reduce exposure to potential irritants like pesticides and synthetic compounds. These clean ingredients support a more natural approach to infant nutrition, potentially reducing inflammatory responses contributing to colic and spit-up.

» Tired of commercial formulas? Explore soy and dairy-free alternatives

Best overall formula for colic and spit-up

1


Superior
10
Else Nutrition Plant-Based Complete Nutrition Formula
Else Nutrition Plant-Based Complete Nutrition Formula
Else Nutrition Plant-Based Complete Nutrition Formula

Else Nutrition Plant-Based Complete Nutrition Formula

Nourishing little ones naturally

Price

$34.99


Volume

22 oz / 623 g


Age

12+ months

Else Nutrition is at the forefront of infant nutrition, redefining the standard with its innovative, plant-based formula.

This modern approach prioritizes clean, organic ingredients, offering a gentle and nutritious solution that supports healthy growth and development.

By minimizing digestive discomfort, it can help reduce colic and spit-up, leading to happier and healthier babies.

Organic and plant-based ingredients

Contains 24 vitamins and minerals

Easy to digest for sensitive babies

Contains almond butter (potential nut allergy concern)

Only suitable for kids over 12 months

Best quick-relief formula for colic and spit-up

2


Outstanding
9.8
a canister of good start for excessive crying, coughs, and gas
a can of food with a blue lid
a can of gerber good start soothe humo infant formula

Gerber Good Start SoothePro

Price

$52.20


Volume

19.4 oz / 549 g


Age

0–12 months

Gerber's SoothePro is a specialized infant formula designed to provide targeted relief for colicky babies. By incorporating specific probiotics and carefully selected proteins, this innovative formula helps soothe fussy babies and reduce the frequency and severity of colic episodes.

Contains Lactobacillus reuteri probiotic

Easy-to-digest proteins

Supports digestive health

Not suitable for babies with milk/soy allergies

Potential digestive adjustment period

Best formula for colic and spit-up for sensitive tummies

3


Excellent
9.6
Similac® 360 Total Care® Sensitive* Infant Formula
Similac® 360 Total Care® Sensitive* Infant Formula
Similac® 360 Total Care® Sensitive* Infant Formula

Similac® 360 Total Care® Sensitive* Infant Formula

Price

$49.99


Volume

30.2 oz / 856 g


Age

12–16 months

By incorporating human milk oligosaccharides, Similac's 360 Total Care Sensitive provides a comprehensive nutritional foundation that promotes optimal development.

These prebiotics work to stimulate the growth of beneficial bacteria, creating a more balanced and comfortable digestive environment.

Five human milk oligosaccharides

Supports good bacteria growth

Includes DHA for brain health

Not suitable for babies with milk/soy allergies

More costly than other options

Best formula for colic and spit-up settling for reducing gas

4


Great
9.3
a close up of a container of gentle infant formula
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a can of gentle infant formula with iron

Mama Bear Gentle Premium Baby Formula Powder

Price

$29.99


Volume

21.05 oz / 610 g


Age

0–12 months

Mama Bear's formula is a smart choice for parents. With its reduced lactose and easily digestible proteins, it offers a practical solution for supporting infant digestive health without breaking the bank.

Partially hydrolyzed whey protein

Human milk oligosaccharides

Reduced lactose content

Contains non-fat milk

Potential lactose sensitivity

Best soothing formula for colic and spit-up for fussy babies

5


Very good
9.1
Enfamil Nutramigenamino alternative formula
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a can of nutramger in all 50 states

Nutramigen with Probiotic LGG Hypoallergenic Infant Formula

Price

$37.99


Volume

12.6 oz / 357 g


Age

0–12 months

Enfamil's Nutramigen takes a clinical approach to infant nutrition, offering a specialized formula for infants with complex digestive and allergic needs.

By incorporating hypoallergenic proteins and probiotics, it provides a targeted nutritional solution backed by scientific research.

Hypoallergenic formula

27 vitamins and minerals with DHA

Contains LGG probiotic

Contains casein (milk protein)

Reported unpleasant smell



Tips for Soothing Colic and Managing Spit-Up

Beyond feeding your baby a suitable formula, there are other things you can do to make your baby more comfortable and reduce their symptoms:

  • Upright Positioning: Hold your baby upright for at least 30 minutes after feeding. Use incline wedges during rest times.

  • Optimized Feeding: Practice paced bottle feeding, frequent burping, and smaller, more frequent feedings.

  • Soothing Movement: Use gentle techniques like swaying, walking, rocking, and abdominal massages.

  • Calming Environment: Create a sensory-friendly space with white noise, soft lighting, and a stable temperature.

  • Natural Remedies: Consider warm compresses, bicycle leg movements, probiotic drops, and chamomile tea (consult your pediatrician first).

  • Emotional Well-Being: Practice self-care, build a support network and remember that these challenges are temporary.

» Learn how to switch from ready-made to powder formula

Easing Your Baby's Discomfort

The sleepless nights and constant worry about your baby's tummy troubles can be overwhelming. Every cry, every spit-up feels like a personal challenge. But remember, your baby isn't trying to make things difficult; they're simply navigating the complexities of their new world.

Although babies usually outgrow colic and spit up after a few months, there are things you can do as a parent to ease their symptoms and make it easier for you. The right formula can make a big difference.

Plant-based formulas like Else Nutrition offer a modern solution that prioritizes both nutritional needs and digestive comfort. By utilizing carefully selected plant-based ingredients, these formulas can help soothe sensitive tummies and promote overall well-being.

four cans of organic toddler organic infant food

A safe and gentle dairy and soy-free formula for your baby

Gentle on sensitive tummies

Free of soy, dairy, gluten, corn syrup, and GMOs

Made with over 90% minimally-processed wholefood ingredients




The content and advice provided in this article are for informational purposes only and are not a substitute for medical diagnosis, treatment, or advice for specific medical conditions.

Always consult a pediatrician to understand your child's needs. The article expresses the views of the article's editor.